Biostimulators: A Guide to Skin Rejuvenation

Biostimulators are advanced injectable treatments designed to enhance skin quality by stimulating collagen production and improving skin hydration, elasticity, and overall texture. Unlike traditional dermal fillers, which provide immediate volume, biostimulators work gradually to rejuvenate the skin from within. Below is an overview of five leading biostimulators available in aesthetic medicine: Gouri, Radiesse, Sculptra, Rejuran, and Profhilo.

Biostimulator	Main Ingredient	Primary Action	Key Benefits	Best For
Gouri	Polycaprolactone (PCL)	Even collagen stimulation across the face	Improves skin elasticity, firmness, and hydration	Global facial rejuvenation
Radiesse	Calcium Hydroxylapatite (CaHA)	Collagen and elastin stimulation with immediate volume	Lifting effect, long-lasting collagen production	Jawline, cheeks, and hands
Sculptra	Poly-L-lactic Acid (PLLA)	Deep collagen induction	Gradual volume restoration, skin tightening	Sunken cheeks, temples, and overall anti-aging
Rejuran	Polynucleotides (PN)	Skin healing and repair	Regenerates damaged skin, enhances hydration	Acne scars, fine lines, sensitive skin
Profhilo	Hyaluronic Acid (HA)	Deep skin hydration and collagen stimulation	Improves skin laxity, hydration, and firmness	Crepey skin, neck, and décolletage

Gouri

How it Works: The first fully liquid polycaprolactone (PCL) injectable, Gouri spreads evenly throughout the skin to stimulate collagen synthesis naturally.
Ideal Candidates: Those seeking overall skin rejuvenation, hydration, and elasticity without excessive volume enhancement.
Treatment Areas: Face, including fine lines and sagging skin.
Results: Gradual improvement over 4–6 weeks, with optimal effects seen at 3 months.
Recommended Treatment Plan: 2–3 sessions spaced 6-8 weeks apart, with maintenance every 6–12 months.

Radiesse

How it Works: Composed of Calcium Hydroxylapatite (CaHA) microspheres, Radiesse provides immediate volume while stimulating collagen and elastin over time.
Ideal Candidates: Patients looking for defined contours and firming effects on areas like the jawline, cheeks, and hands.
Treatment Areas: Jawline, cheeks, hands, neck.
Results: Immediate lifting effect with collagen stimulation over 3–6 months, lasting 12–18 months.
Recommended Treatment Plan: 1–2 sessions, with maintenance every 12–18 months.

Sculptra

How it Works: Made of Poly-L-lactic Acid (PLLA), Sculptra acts as a deep tissue collagen stimulator that restores lost volume and improves skin texture over time.
Ideal Candidates: Those with significant volume loss, particularly in the midface, temples, or nasolabial folds.
Treatment Areas: Cheeks, temples, lower face.
Results: Gradual improvement over several months, lasting up to 2 years.
Recommended Treatment Plan: 3 sessions spaced 4–6 weeks apart, with maintenance every 18–24 months.

Rejuran

How it Works: Derived from salmon DNA (Polynucleotides, PN), Rejuran has powerful skin-repairing and anti-inflammatory properties.
Ideal Candidates: Those with acne scars, sensitive skin, fine lines, and early signs of aging.
Treatment Areas: Face, under-eyes, neck.
Results: Skin repair begins within 2–4 weeks, with continued improvement over 3 months.
Recommended Treatment Plan: 3–4 sessions spaced 2–4 weeks apart, with maintenance every 6–9 months.

Profhilo

How it Works: A unique hyaluronic acid (HA)-based biostimulator that deeply hydrates and stimulates collagen and elastin production.
Ideal Candidates: Patients with dehydrated, sagging, or crepey skin.
Treatment Areas: Face, neck, hands, arms, décolletage.
Results: Visible skin quality improvement in 2–3 weeks, with full effects in 8 weeks.
Recommended Treatment Plan: 2 sessions spaced 4 weeks apart, with maintenance every 6 months.

Which Biostimulator is Right for You?

Choosing the right biostimulator depends on your skin concerns and treatment goals. If you seek:

Hydration and skin elasticity → Profhilo

Firming and defined contours → Radiesse

Volume restoration and deep collagen stimulation → Sculptra

Skin repair and anti-inflammatory effects → Rejuran

Overall collagen stimulation with natural results → Gouri

Frequently Asked Questions (FAQs)

How soon will I see results from a biostimulator treatment?

Most biostimulators take 6-8 weeks to show noticeable effects, with optimal results seen at 3–6 months depending on the product.

How long do the results last?

The longevity varies:

Profhilo – ~6 months

Rejuran – ~6–12 months

Radiesse – 12–18 months

Gouri – 12 months

Sculptra – Up to 2 years

Are biostimulators safe?

Yes, biostimulators are generally considered safe when administered by qualified healthcare professionals. The substances used are biocompatible and have been extensively studied. However, as with any medical procedure, it’s essential to discuss your medical history and any concerns with your practitioner to ensure the treatment is appropriate for you.

Can I combine biostimulators with other treatments?

Absolutely! Many patients combine biostimulators with treatments like lasers, microneedling, or dermal fillers for enhanced results.

What are the possible side effects of biostimulator treatments?

Common side effects include mild redness, swelling, bruising, tenderness, or itching at the injection site. These effects are typically temporary and resolve within a few days. In rare cases, small lumps may form under the skin; massaging the area as directed by your practitioner can help minimize this risk.

How do biostimulators differ from traditional dermal fillers?

While traditional dermal fillers provide immediate volume by adding substances like hyaluronic acid beneath the skin, biostimulators work by stimulating the body’s natural collagen production over time. This leads to gradual, natural-looking improvements in skin texture, firmness, and volume.

What should I do before and after a biostimulator treatment?

Before treatment, avoid blood-thinning medications and supplements to reduce the risk of bruising. After treatment, follow your provider’s instructions, which may include massaging the treated area, avoiding excessive sun exposure, and refraining from high-intensity exercise for a specified period.

Final Thoughts

Biostimulators offer an incredible long-term approach to skin rejuvenation by enhancing your skin’s natural regenerative processes rather than simply masking signs of aging. These treatments stimulate collagen, improve elasticity, and restore volume in a way that complements your natural beauty.

Choosing the right biostimulator is not just about addressing visible concerns; it’s about understanding your skin’s unique needs and creating a plan that offers the best results over time. Whether you’re looking for hydration, firming, lifting, or deep tissue repair, each biostimulator has its own advantages, and we are here to guide you toward the most suitable treatment for your goals.

Remember, skin health is a journey, and with the right approach, you can maintain a youthful, vibrant appearance for years to come.

Biostimulators: A Guide to Skin Rejuvenation